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. 2020 Aug 6;22:57. doi: 10.1186/s12968-020-00655-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Fibrosis on histology and T1-mapping data. Examples of diffuse fibrosis in mice subjected to systemic hypertension for 6 weeks on histology - picrosirius red staining (A). The relationship between fibrosis on histology and the native T1-values (B), post contrast T1-values (C) and the extracellular volume (D). While native T1 and ECV showed a positive correlation with histological fibrosis due to kinetics of the contrast agent’s myocardial clearance, post-contrast T1 values are negatively correlated with histological fibrosis. Hearts from 20 hypertensive animals sacrificed immediately after imaging (during the infusion of angiotensin II at the 2-week (n = 5), 4-week (n = 3) and 6-week (n = 12) timepoint) were used for this analysis. Pearson’s correlation coefficient