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. 2020 Aug 6;20:396. doi: 10.1186/s12888-020-02713-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Relationship between treatment condition (i.e. EMDR, EMDR-DBT) and primary outcome measures (i.e. post-treatment scores on the CAPS-5 and SCID-5-PD), proposedly mediated by pre-to post-stressor changes in levels of cortisol, FKBP5 and BDNF protein levels and FKBP5 and BDNF methylation status. It is hypothesized that the regression of the primary outcome measures on treatment condition, ignoring the mediators, will be significant (c1). Secondly, the regression of the mediators cortisol, FKBP5 and BDNF protein levels and FKBP5 and BDNF methylation status on treatment condition are hypothesized to be significant as well (a1, a2 and a3 resp.). In addition, the regression of the primary outcome measures on the mediators are also expected to be significant (b1, b2 and b3 resp.). Lastly, it is hypothesized that, when controlling for the mediators, treatment condition will significantly predict the scores on the CAPS-5 and SCID-5-PD, supporting partial mediation