Table 2.
Univariate and multivariate analysis for OS
| Variables | OS | PFS | ||||
|---|---|---|---|---|---|---|
| Univariate | Multivariate | p value | Univariate | Multivariate | p value | |
| p value | HR(95% CI) | p value | HR(95% CI) | |||
| Age, years(> 50 vs. ≤ 50) | 0.911 | NA | 0.713 | NA | ||
| Gender(male vs. female) | 0.873 | NA | 0.115 | NA | ||
| HBsAg (positive vs. negative) | 0.065 | NS | 0.001 | 3.717(1.504–9.185) | 0.004 | |
| AFP, ng/ml (> 20 vs. ≤ 20) | 0.094 | NS | 0.262 | NA | ||
| Cirrhosis (yes vs. no) | 0.036 | 2.098(1.240–3.550) | 0.006 | 0.018 | 2.217(1.441–3.412) | 0.000 |
| Tumor number (multiple vs. single) | 0.122 | NA | 0.001 | 1.530(1.182–1.981) | 0.001 | |
| Tumor size, cm (> 5 vs. ≤ 5) | 0.005 | 1.893(1.059–3.384) | 0.031 | 0.000 | 2.690(1.693–4.275) | 0.000 |
| Tumor differentiation (III vs. I-II) | 0.124 | NA | 0.111 | NA | ||
| vascular invasion (present vs. absent) | 0.000 | 4.171(1.830–9.504) | 0.001 | 0.038 | NS | |
| LAG-3 expression (high vs. low) | 0.009 | 1.879(1.080–3.267) | 0.025 | 0.012 | 1.642(1.058–2.549) | 0.027 |
| CD8 expression (high vs. low) | 0.007 | 0.562(0.330–0.957) | 0.034 | 0.000 | 0.618(0.400–0.956) | 0.031 |
| PD-L1 status on TC (positive vs. negative) | 0.122 | NA | 0.065 | NS | ||
| PD-L1 status on IC (positive vs. negative) | 0.938 | NA | 0.074 | NS | ||
| FGL1 status on TC (positive vs. negative) | 0.489 | NA | 0.968 | NA | ||
| FGL1 status on IC (positive vs. negative) | 0.144 | NA | 0.584 | NA | ||
P < 0.05 was considered as statistically significant
HOS overall survival, DFS disease-free survival, HBsAg hepatitis B surface antigen, AFP αfetoprotein, HR hazard ratio, CI confidential interval, NA not adopted, NS not significant, TC tumor cells, IC immune cells