Table 5.

Subgroup analysis results

Subgroup analyses	No. of papers	No. of patients	Sen	Spe	PLR	NLR	DOR	SROC (SE)
Overall studies	7	1285	0.75 (0.70–0.79)	0.69 (0.66–0.72)	3.01 (1.84–4.93)	0.32 (0.19–0.53)	10.2 (3.63–28.64)	0.8288 (0.0525)
Type of blood sample
Plasma	3	787	0.67 (0.60–0.73)	0.60 (0.56–0.64)	1.59 (1.28–1.99)	0.59 (0.48–0.72)	2.69 (1.92–3.77)	0.6599 (0.0261)
Serum	4	498	0.86 (0.80–0.91)	0.84 (0.80–0.88)	4.91 (2.85–8.48)	0.19 (0.09–0.37)	28.25 (9.60–83.15)	0.9096 (0.0332)

Sen sensitivity, Spe specificity, PLR positive likelihood ratio, NLR negative likelihood ratio, DOR diagnostic odds ratio, SROC summary receiver operating characteristic, SE standard error