Table 3.
Pre- and post-treatment laboratory values and changes with treatment
| Black | White | Adjusted Difference in Δ between Whites and Blacksa (95% Confidence Interval) | P Value (Difference in Δ between Whites and Blacks) | |||||
|---|---|---|---|---|---|---|---|---|
| Pre (SD) | Post (SD) | Δ (95% Confidence Interval)a | Pre (SD) | Post (SD) | Δ (95% Confidence Interval)a | |||
| N | 77 | 107 | ||||||
| Age, yr | 52 (12) | 49 (14) | ||||||
| Weight, kg | 87 (20) | 80 (24) | ||||||
| Men/women | 28/49 | 56/51 | ||||||
| Serum values | ||||||||
| Sodium, mmol/L | 140.7 (1.8) | 140.1 (1.8) | −0.5 (−0.7 to 0.4) | 139.7 (1.8) | 139.5 (2.0) | −0.3 (−0.4 to −0.2) | 0.2 (−0.3 to 0.7) | 0.35 |
| Potassium, mmol/L | 4.2 (0.3) | 4.2 (0.4) | 0.02 (−0.02 to 0.06) | 4.3 (0.3) | 4.1 (0.4) | −0.2 (−0.3 to −0.1) | −0.2 (−0.3 to −0.1) | 0.002 |
| Bicarbonate, mmol/L | 26.7 (2.1) | 26.5 (2.6) | −0.2 (−0.4 to 0.0) | 26.6 (2.0) | 27.6 (2.5) | 1.1 (0.9 to 1.3) | 1.3 (0.7 to 1.8) | <0.001 |
| Calcium, mg/dl | 9.5 (0.3) | 9.6 (0.3) | 0.05 (0.02 to 0.08) | 9.6 (0.3) | 9.7 0.4) | 0.1 (0.07 to 0.03) | 0.06 (−0.1 to 0.03) | 0.18 |
| Phosphate, mg/dl | 3.2 (0.4) | 3.3 (0.5) | 0.07 (0.02 to 0.11) | 3.5 (0.4) | 3.4 (0.6) | −0.06 (−0.15 to 0.03) | −0.1 (−0.3 to 0.01) | 0.06 |
| Creatinine, mg/dl | 1.1 (0.3) | 1.2 (0.4) | 0.08 (0.04 to 1.12) | 1.0 (0.3) | 1.0 (0.4) | −0.02 (−0.05 to 0.01) | −0.1 (−0.2 to 0.0) | 0.05 |
| 24-h urine values | ||||||||
| Volume, L/d | 1.4 (0.7) | 1.9 (0.8) | 0.4 (0.3 to 0.5) | 1.9 (0.6) | 2.4 (0.8) | 0.5 (0.4 to 0.6) | 0.00 (−0.25 to 0.27) | 0.95 |
| pH | 5.9 (0.4) | 6.2 (0.4) | 0.3 (0.2 to 0.4) | 6.0 (0.4) | 6.1 (0.4) | 0.2 (0.1 to 0.3) | −0.1 (−0.2 to −0.01) | 0.04 |
| Creatinine, mg/d | 1500 (281) | 1602 (272) | 143 (112 to 174) | 1412 (279) | 1425 (269) | −17 (−43 to 8) | −160 (−242 to −77) | <0.001 |
| Sodium, mmol/d | 138 (48) | 180 (67) | 40 (32 to 48) | 163 (48) | 158 (66) | −4 (−11 to 3) | −45 (−65 to −24) | <0.001 |
| Potassium, mmol/d | 42 (18) | 55 (24) | 9 (7 to 11) | 59 (18) | 64 (23) | 8 (6 to 10) | −1 (−8 to 6) | 0.89 |
| Calcium, mg/d | 115 (94) | 158 (79) | 6 (−3 to 15) | 233 (101) | 169 (76) | −38 (−46 to −30) | −44 (−68 to −20) | <0.001 |
| Magnesium, mg/d | 75 (37) | 97 (32) | 10 (6 to 14) | 105 (37) | 98 (31) | 0 (−3 to 3) | −9 (−19 to 0.3) | 0.08 |
| Sulfate, meq/d | 33 (13) | 39 (12) | 4 (3 to 6) | 46 (13) | 47 (11) | 2 (1 to 3) | −2 (−6 to 1) | 0.21 |
| Ammonium, meq/db | 29 (12) | 31 (15) | 3 (2 to 4) | 32 (13) | 35 (14) | 3 (2 to 4) | 0 (−4 to 4) | 0.91 |
| Phosphate, mg/d | 638 (202) | 795 (228) | 104 (76 to 132) | 962 (207) | 902 (278) | −22 (−46 to 2) | −125 (−199 to 52) | 0.001 |
| Oxalate, mg/d | 37 (15) | 42 (14) | 5 (4 to 7) | 39 (15) | 41 (13) | 1 (−1 to 3) | −5 (−10 to 0) | 0.04 |
| Citrate, mg/d | 417 (307) | 516 (316) | 74 (45 to 103) | 553 (310) | 514 (309) | −21 (−45 to 3) | −95 (−170 to 19) | 0.01 |
| Uric acid, mg/d | 489 (131) | 581 (132) | 83 (61 to 99) | 634 (134) | 641 (134) | 14 (11 to 17) | −70 (−117 to −23) | 0.004 |
| Urea nitrogen, g/d | 8.6 (8.5) | 10.4 (4.8) | 1.4 (0.9 to 1.9) | 10.6 (3.4) | 10.9 (1.9) | 0.3 (0.2 to 0.4) | −1.2 (−2.6 to 0.2) | 0.10 |
| Sodium + potassium, meq/d | 180 (57) | 233 (68) | 51 (43 to 59) | 222 (61) | 224 (67) | 3 (−4 to 10) | −46 (−69 to −24) | <0.001 |
| Clearance H2O, ml/d | 163 (470) | 385 (891) | 92 (−9 to 192) | 426 (445) | 706 (893) | 410 (321 to 499) | 318 (49 to 588) | 0.02 |
| Creatinine clearance, ml/min | 98 (32) | 108 (23) | 5 (3 to 7) | 106 (31) | 103 (23) | −1 (−3 to 1) | −6 (−13 to 0.4) | 0.06 |
| Supersaturation calcium oxalate | 8.0 (3.7) | 5.8 (3.5) | −1.9 (−2.4 to −1.5) | 7.2 (3.8) | 5.6 (3.5) | −1.7 (−2 to −1.4) | 0.2 (−1 to 1.4) | 0.73 |
| Supersaturation calcium phosphate | 0.8 (0.7) | 0.9 (0.6) | 0 (−0.1 to 0.1) | 1.2 (0.8) | 0.8 (0.6) | −0.3 (−0.4 to −0.2) | 0.3 (−0.5 to −0.05) | 0.02 |
| Supersaturation uric acid | 1.3 (0.7) | 0.8 (0.6) | −0.4 (−0.5 to −0.3) | 1.0 (0.8) | 0.7 (0.6) | −0.4 (−0.5 to −0.3) | 0.1 (−0.1 to 0.3) | 0.48 |
a
All values are adjusted for individual pretreatment values and sex. All urine values are adjusted for 24-hour urine creatinine and weight (except pH, supersaturations, and creatinine clearance).
b
Adjusted for urine sulfate. All P values are Bonferroni adjusted.