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. 2020 Jul 1;15(8):1090–1102. doi: 10.2215/CJN.01030120

Table 3.

Associations of participant characteristics with serious adverse drug reactions

Characteristics N (%) with Adverse Drug Reactions, n=125 Incidence Ratea Unadjusted Model Adjusted Model
Incidence Rate [95% Confidence Interval] Hazard Ratio [95% Confidence Interval] P Value Hazard Ratio [95% Confidence Interval] P Value
Age, yr 0.15 0.32
 <60 26 (4) 2.4 [0.9 to 6.9] Reference Reference
 60–75 52 (4) 2.4 [1.1 to 5.1] 1.02 [0.64 to 1.63] 0.71 [0.44 to 1.17]
 ≥75 47 (5) 3.4 [1.6 to 7.5] 1.45 [0.90 to 2.34] 0.91 [0.54 to 1.51]
Sex 0.91 0.74
 Men 82 (4) 2.7 [1.5 to 4.8] Reference Reference
 Women 43 (4) 2.8 [1.3 to 6.0] 0.98 [0.68 to 1.42] 1.06 [0.73 to 1.55]
eGFR, ml/min per 1.73 m2 <0.001 0.01
 ≥30 49 (3) 1.8 [0.9 to 3.4] Reference Reference
 <30 76 (6) 4.0 [2.4 to 6.8] 2.17 [1.51 to 3.11] 1.82 [1.25 to 2.63]
BMI, kg/m2 0.05 0.46
 <30 70 (4) 2.4 [1.3 to 4.5] Reference Reference
 ≥30 55 (5) 3.3 [1.6 to 6.8] 1.42 [0.99 to 2.04] 1.16 [0.79 to 1.70]
Anemiab 0.001 0.15
 Without anemia 60 (3) 2.0 [1.0 to 4.1] Reference Reference
 With anemia 65 (5) 3.9 [2.0 to 7.5] 1.77 [1.25 to 2.52] 1.31 [0.91 to 1.89]
Diabetes 0.03 0.89
 Without diabetes 60 (3) 2.3 [1.2 to 4.3] Reference Reference
 With diabetes 65 (5) 3.3 [1.8 to 6.1] 1.47 [1.03 to 2.09] 0.97 [0.65 to 1.44]
AKI history 0.01 0.12
 Without AKI history 84 (4) 2.3 [1.3 to 4.2] Reference Reference
 With AKI history 41 (6) 4.0 [1.8 to 9.3] 1.67 [1.12 to 2.49] 1.37 [0.92 to 2.05]
Cardiovascular history <0.001 0.01
 Without cardiovascular history 35 (2) 1.5 [0.7 to 3.4] Reference Reference
 With cardiovascular history 90 (6) 3.9 [2.4 to 6.3] 2.45 [1.65 to 3.63] 1.93 [1.25 to 2.98]
Baseline no. of drugs per patients <0.001 0.05
 <5 10 (2) 1.1 [0.2 to 4.6] Reference Reference
 5–10 62 (4) 2.4 [1.3 to 4.3] 2.29 [1.17 to 4.46] 1.53 [0.76 to 3.10]
 >10 53 (3) 5.0 [2.7 to 9.4] 4.70 [2.39 to 9.23] 2.31 [1.07 to 5.01]
Adherence to medication 0.01 0.03
 Good 30 (3) 1.8 [0.8 to 4.3] Reference Reference
 Poor 95 (5) 3.3 [2.0 to 5.4] 1.95 [1.29 to 2.94] 1.59 [1.05 to 2.42]

P values used the Wald chi-squared test for global variable effect. BMI, body mass index.

a

Incidence rates are expressed per 100 person-years.

b

Anemia is defined by the 1968 World Health Organization (51) definition: <12 g/dl for women and <13 g/dl for men.