Table 4.
Description of adverse drug reactions according to baseline eGFR
| Type of Adverse Drug Reaction | All Adverse Drug Reactions, n=751 | Adverse Drug Reactions in Patients with eGFR≥30, n=331 | Adverse Drug Reactions in Patients with eGFR<30, n=420 |
|---|---|---|---|
| Renal and urinary disorders | 150 (20%) | 62 (19%) | 88 (21%) |
| AKI | 102 | 41 | 61 |
| Increased serum creatinine | 40 | 20 | 20 |
| Other type of renal and urinary disorders | 8 | 1 | 7 |
| Gastrointestinal disorders | 119 (16%) | 61 (18%) | 58 (14%) |
| Diarrhea | 57 | 35 | 22 |
| Gastrointestinal conditions | 24 | 8 | 16 |
| Other type of gastrointestinal disorders | 38 | 18 | 20 |
| Musculoskeletal and connective tissue disorders | 68 (9%) | 34 (10%) | 34 (8%) |
| Contractures | 35 | 21 | 14 |
| Muscle pain | 22 | 10 | 12 |
| Other type of musculoskeletal and connective tissue disorders | 11 | 3 | 8 |
| Hemorrhages and bleeding | 67 (9%) | 18 (5%) | 49 (12%) |
| Hemorrhages | 34 | 8 | 26 |
| Hematoma | 19 | 7 | 12 |
| Other type of hemorrhages and bleeding | 14 | 3 | 11 |
| General disorders and administration site conditions | 58 (8%) | 26 (8%) | 32 (8%) |
| Peripheral edema | 30 | 11 | 19 |
| Drug intolerance | 8 | 3 | 5 |
| Other type of general disorders and administration site conditions | 20 | 12 | 8 |
| Other type of adverse drug reactions | 289 (38%) | 130 (39%) | 159 (38%) |
eGFR is expressed in milliliters per minute per 1.73 m2. Results are expressed as n (%). The denominator used in column 2 is the total number of adverse drug reactions, and the denominators used in columns 3 and 4 are those of the adverse drug reactions in patients with eGFR<30 versus ≥30, respectively. P=0.03 tests the difference in the distribution of adverse drug reaction type according to patient baseline eGFR.