Table 2.

Macrophages, CD38, and nad metabolism.

Species	Cell Type	Stimulus/Condition	Effect	Reference
C57BL/6J mice	BMDM	Cytokines, TLR ligands LPS	↑ CD38	[141]
C57BL/6J mice	WAT mϕ	LPS	↑ CD38 ↑ TNFα, IL-1β ↑ mϕ	[141]
C57BL/6J mice	BMDM	Senescent media	↑ CD38	[141]
C57BL/6J mice	Liver and WAT mϕ	Doxorubicin	↑ CD38+ mϕ	[141]
C57BL/6J mice	Kupffer cells	Aging (25 months old compared to 6 months)	↑ CD38, p21, NAMPT, IL-1β, IL-18, CCL2, HMGB1 ↑ mϕ ↑ M1 polarization	[141]
Human (cell line)	HEK293T	CD38 overexpression	↓ mitochondrial respiratory capacity ↓ NAD Abnormal mitochondrial morphology	[151]
C57BL/6 mice	Isolated liver mitochondria	CD38 KO vs WT	↑ respiratory rate ↑ NAD and NAD/NADH ↑ SIRT3	[151]
Human	Monocytes	Epigenetic age reversal intervention	↓ CD38+ monocytes	[158]
Human (cell line)	THP-1, U937	LPS + IFNγ	↑ CD38 vs M0 or M2	[155]
Human (cell line)	THP-1, U937	CD38 inhibition via apigenin or rhein in M1 (LPS + IFNγ)	↓ IL-6, IL-12p40	[155]
C57BL/6 mice	BMDC	CD38 KO vs WT with collagen-induced arthritis	↓ phospho-NFκB ↓ IL-1β, IL-4, IL-10	[162]
Mouse (cell line)	RAW 264.7	LPS	CD38 activation	[154]
Mouse (cell line)	RAW 264.7	LPS stimulation with CD38 inhibition via quercetin	↓ phospho-NFκB ↓ M1 polarization	[154]
C57BL/6 mice	Kidney mϕ	LPS stimulation with CD38 inhibition via quercetin	↓ mϕ accumulation ↓ CCL2 and TNFα ↓ M1 polarization ↓ phospho-NF-κB	[154]

BMDC: bone marrow-derived dendritic cells; BMDM: bone marrow-derived macrophages, CD: cluster of differentiation; IFN: interferon; IL: interleukin; KO: knockout; LPS: lipopolysaccharide; WAT: white adipose tissue; WT: wildtype.