Table 2.
Species | Cell Type | Stimulus/Condition | Effect | Reference |
---|---|---|---|---|
C57BL/6J mice | BMDM | Cytokines, TLR ligands LPS | ↑ CD38 | [141] |
C57BL/6J mice | WAT mϕ | LPS | ↑ CD38 ↑ TNFα, IL-1β ↑ mϕ |
[141] |
C57BL/6J mice | BMDM | Senescent media | ↑ CD38 | [141] |
C57BL/6J mice | Liver and WAT mϕ | Doxorubicin | ↑ CD38+ mϕ | [141] |
C57BL/6J mice | Kupffer cells | Aging (25 months old compared to 6 months) | ↑ CD38, p21, NAMPT, IL-1β, IL-18, CCL2, HMGB1 ↑ mϕ ↑ M1 polarization |
[141] |
Human (cell line) | HEK293T | CD38 overexpression | ↓ mitochondrial respiratory capacity ↓ NAD Abnormal mitochondrial morphology |
[151] |
C57BL/6 mice | Isolated liver mitochondria | CD38 KO vs WT | ↑ respiratory rate ↑ NAD and NAD/NADH ↑ SIRT3 |
[151] |
Human | Monocytes | Epigenetic age reversal intervention | ↓ CD38+ monocytes | [158] |
Human (cell line) | THP-1, U937 | LPS + IFNγ | ↑ CD38 vs M0 or M2 | [155] |
Human (cell line) | THP-1, U937 | CD38 inhibition via apigenin or rhein in M1 (LPS + IFNγ) | ↓ IL-6, IL-12p40 | [155] |
C57BL/6 mice | BMDC | CD38 KO vs WT with collagen-induced arthritis | ↓ phospho-NFκB ↓ IL-1β, IL-4, IL-10 |
[162] |
Mouse (cell line) | RAW 264.7 | LPS | CD38 activation | [154] |
Mouse (cell line) | RAW 264.7 | LPS stimulation with CD38 inhibition via quercetin | ↓ phospho-NFκB ↓ M1 polarization |
[154] |
C57BL/6 mice | Kidney mϕ | LPS stimulation with CD38 inhibition via quercetin | ↓ mϕ accumulation ↓ CCL2 and TNFα ↓ M1 polarization ↓ phospho-NF-κB |
[154] |
BMDC: bone marrow-derived dendritic cells; BMDM: bone marrow-derived macrophages, CD: cluster of differentiation; IFN: interferon; IL: interleukin; KO: knockout; LPS: lipopolysaccharide; WAT: white adipose tissue; WT: wildtype.