Fig. 10.1.

Functional features of short-term repopulating HSCs (STR-HSC) and long-term repopulating HSCs (LTR-HSC). (a) LTR-HSCs display long-term self-renewal and repopulating capacity, whereas STR-HSCs exhibit short-term self-renewal and repopulating capacity. (b) During homeostasis, the majority of LTR-HSCs are CD34^neg, and are quiescent and dividing infrequently. In response to stress and injury, dormant HSCs are activated and start to express CD34, and cycle more frequently. Activated HSCs are maintaining themselves and are generating STR-HSCs through asymmetric self-renewal divisions. After restoring homeostasis of the hematopoietic system, activated HSCs return to a quiescent state