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Lineage-biased HSC subsets exhibit in vivo lineage differentiation bias. Lineage-balanced HSCs produce balanced amounts of myeloid and lymphoid progeny. Myeloid-biased HSCs exhibit long-term self-renewal capacity and myeloid differentiation bias. Lymphoid-biased HSCs display lymphoid differentiation bias and lower self-renewal capacity and proliferate more frequently. Megakaryocyte-biased HSCs display megakaryocytic/platelet-biased differentiation capacity
