Table 2. Characteristics of five DNA methylation-based diagnostic biomarkers in ccRCC diagnosis.
| Gene symbol | CpGs | Differential expressiona (log2FC) |
Differential methylationb level | Correlationc | Distance from TSS (bp) |
CpG island |
|---|---|---|---|---|---|---|
| NAT8 | cg19565262 | 2.73 | −0.49 | −0.46 | −445 | . |
| ALOX5 | cg07355189 | 1.64 | 0.56 | 0.74 | 3,841 | Island |
| PDE1A | cg00470341 | −3.43 | −0.53 | 0.74 | 53,972 | . |
| PDE8B | cg12559197 | −1.10 | −0.55 | 0.70 | 1,48,031 | . |
| PFKP | cg15087907 | 1.62 | 0.47 | 0.51 | 13,608 | . |
Notes:
a
The log2-transformed fold changes between the tumor and benign-adjacent tissues (>0 means over-expression in tumor tissues) in ccRCCs.
b
The differential methylation levels between the tumor and benign-adjacent tissues (>0 means hypermethylation in tumor tissues) in ccRCCs.
c
The Spearman’s rank correlations between gene expression and probe methylation levels in ccRCCs.