Table 3. Multivariate Cox regression analysis of the eight-CpG-based prognostic model with overall survival in the TCGA datasets.
| Parameters | HR | (CI 95%) HR Lower |
(CI 95%) HR Upper |
SE | Z value | p Value | |
|---|---|---|---|---|---|---|---|
| Gender | Male vs. Female | 0.65 | 0.31 | 1.4 | 0.38 | −1.10 | P = 0.27 |
| Age | Younger than 62 years versus 62 years or old | 1.0 | 0.92 | 1.1 | 0.016 | 2.61 | P = 0.011 |
| pT | T1/2 versus T3/4 | 1.9 | 1.4 | 2.8 | 0.19 | 3.62 | P < 0.001 |
| pN | N0 versus N1 | 1.1 | 0.53 | 2.3 | 0.37 | 0.26 | P = 0.8 |
| M | M0 versus M1 | 1.4 | 0.78 | 2.5 | 0.31 | 1.10 | P = 0.26 |
| Stage | T1/2 versus T3/4 | 2.1 | 1.5 | 2.8 | 0.17 | 4.32 | P < 0.001 |
| Eight-CpG-Based model | Low vs. High risk groups | 2.9 | 1.8 | 4.9 | 0.25 | 4.21 | P < 0.001 |
Note:
HR, hazard ratio; CI, 95% confidence interval; SE, standard errors of coefficient; Z value, Wald z-statistic value.