Table 1.
Patient Characteristics
| Characteristic | DCIS patient |
cT1N0 patient |
cT2N0 patient |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ER+ (n = 83,754) |
ER– (n = 15,995) |
NET (n = 1,591) |
Primary operation (n = 221,342) |
NET (n = 1,880) |
Primary operation (n = 54,277) |
|||||||
| n | % | n | % | n | % | n | % | n | % | n | % | |
| Age∗ | ||||||||||||
| 18–39 y | 2,451 | 2.9 | 507 | 3.2 | 29 | 1.8 | 4,818 | 2.2 | 21 | 1.1 | 2,671 | 4.9 |
| 40–49 y | 17,150 | 20.5 | 2,331 | 14.6 | 170 | 10.7 | 30,432 | 13.7 | 157 | 8.4 | 9,827 | 18.1 |
| 50–59 y | 23,593 | 28.2 | 4,661 | 29.1 | 336 | 21.1 | 55,485 | 25.1 | 362 | 19.3 | 13,327 | 24.6 |
| 60–69 y | 23,972 | 28.6 | 48,890 | 30.6 | 492 | 30.9 | 72,239 | 32.6 | 581 | 30.9 | 14,621 | 26.9 |
| 70–79 y | 13,045 | 15.6 | 2,657 | 16.6 | 357 | 22.4 | 45,174 | 20.4 | 449 | 23.9 | 9,223 | 17.0 |
| 80 y or older | 3,543 | 4.2 | 949 | 5.9 | 207 | 13.0 | 13,194 | 6.0 | 310 | 16.5 | 4,608 | 8.5 |
| Race∗ | ||||||||||||
| White | 63,659 | 76.0 | 12,551 | 78.5 | 1,322 | 83.1 | 186,587 | 84.3 | 1,491 | 79.3 | 43,628 | 80.4 |
| Black | 10,665 | 12.7 | 1,643 | 10.3 | 119 | 7.5 | 16,254 | 7.3 | 171 | 9.1 | 4,829 | 8.9 |
| Hispanic | 5,073 | 6.1 | 947 | 5.9 | 93 | 5.8 | 10,278 | 4.6 | 137 | 7.3 | 3,232 | 6.0 |
| Asian | 3,859 | 4.6 | 767 | 4.8 | 47 | 3.0 | 6,961 | 3.1 | 70 | 3.7 | 2,240 | 4.1 |
| Other | 498 | 0.6 | 87 | 0.5 | 10 | 0.6 | 1,262 | 0.6 | 11 | 0.6 | 348 | 0.6 |
| Comorbidity index | ||||||||||||
| 0 | 70,824 | 84.6 | 13,514 | 84.5 | 1,234 | 77.6 | 184,373 | 83.3 | 1,539 | 81.9 | 44,446 | 81.9 |
| 1 | 10,519 | 12.6 | 1,982 | 12.4 | 239 | 15.0 | 29,636 | 13.4 | 241 | 12.8 | 7,757 | 14.3 |
| 2 | 1,853 | 2.2 | 391 | 2.4 | 78 | 4.9 | 5,549 | 2.5 | 68 | 3.6 | 1,524 | 2.8 |
| ≥ 3 | 558 | 0.7 | 108 | 0.7 | 40 | 2.5 | 1,784 | 0.8 | 32 | 1.7 | 550 | 1.0 |
| Insurance∗ | ||||||||||||
| Private | 50,754 | 60.6 | 9,193 | 57.5 | 663 | 41.7 | 117,865 | 53.3 | 713 | 37.9 | 29,021 | 53.5 |
| Medicare | 25,778 | 30.8 | 5,426 | 33.9 | 756 | 47.5 | 86,475 | 39.1 | 953 | 50.7 | 19,431 | 35.8 |
| Medicaid | 4,228 | 5.0 | 789 | 4.9 | 102 | 6.4 | 10,099 | 4.6 | 120 | 6.4 | 3,679 | 6.8 |
| Other government | 931 | 1.1 | 167 | 1.0 | 12 | 0.8 | 2,233 | 1.0 | 20 | 1.1 | 577 | 1.1 |
| Uninsured | 1,225 | 1.5 | 260 | 1.6 | 27 | 1.7 | 2,603 | 1.2 | 43 | 2.3 | 1,016 | 1.9 |
| Unknown | 838 | 1.0 | 160 | 1.0 | 31 | 1.9 | 2,067 | 0.9 | 31 | 1.6 | 553 | 1.0 |
| Region | ||||||||||||
| Metro | 70,858 | 84.6 | 13,422 | 83.9 | 1,296 | 81.5 | 182,504 | 82.5 | 1,571 | 83.6 | 44,633 | 82.2 |
| Urban | 9,558 | 11.4 | 1,902 | 11.9 | 218 | 13.7 | 29,281 | 13.2 | 226 | 12.0 | 7,372 | 13.6 |
| Rural | 1,214 | 1.4 | 257 | 1.6 | 33 | 2.1 | 3,917 | 1.8 | 29 | 1.5 | 962 | 1.8 |
| Unknown | 2,124 | 2.5 | 414 | 2.6 | 44 | 2.8 | 5,640 | 2.5 | 54 | 2.9 | 1,310 | 2.4 |
| Facility type∗ | ||||||||||||
| Community | 6,465 | 8.0 | 1,183 | 7.6 | 112 | 7.2 | 19,278 | 8.9 | 132 | 7.1 | 4,757 | 9.2 |
| Comprehensive | 36,644 | 45.1 | 7,176 | 46.3 | 623 | 39.9 | 98,290 | 45.4 | 717 | 38.6 | 23,671 | 45.9 |
| Academic | 25,206 | 31.0 | 4,674 | 30.2 | 524 | 33.5 | 66,491 | 30.7 | 704 | 37.9 | 15,662 | 30.3 |
| Integrated network | 12,988 | 16.0 | 2,455 | 15.9 | 303 | 19.4 | 32,465 | 15.0 | 306 | 16.5 | 7,516 | 14.6 |
| Histology∗ | ||||||||||||
| Ductal | NA | NA | NA | NA | 1,219 | 76.6 | 176,972 | 80.0 | 1,284 | 68.3 | 39,905 | 73.5 |
| Lobular | NA | NA | NA | NA | 199 | 12.5 | 22,192 | 10.0 | 349 | 18.6 | 8,322 | 15.3 |
| Mixed | NA | NA | NA | NA | 173 | 10.9 | 22,178 | 10.0 | 247 | 13.1 | 6,050 | 11.1 |
| Grade∗ | ||||||||||||
| 1 | 11,314 | 13.5 | 263 | 1.6 | 591 | 27.1 | 77,878 | 35.2 | 498 | 26.5 | 8,971 | 16.5 |
| 2 | 33,311 | 39.8 | 2,149 | 13.4 | 805 | 50.6 | 109,108 | 49.3 | 1,040 | 55.3 | 28,762 | 53.0 |
| 3 | 26,257 | 31.4 | 10,903 | 68.2 | 124 | 7.8 | 25,837 | 11.7 | 267 | 14.2 | 14,529 | 26.8 |
| Unknown | 12,872 | 15.4 | 2,680 | 16.8 | 71 | 4.5 | 8,519 | 3.8 | 75 | 4.0 | 2,015 | 3.7 |
| Operative time from diagnosis | ||||||||||||
| < 60 d | 69,539 | 83.0 | 13,197 | 82.5 | 352 | 22.1 | 199,778 | 90.3 | 137 | 7.3 | 47,598 | 87.7 |
| 61–120 d | 12,689 | 15.2 | 2,504 | 15.7 | 596 | 37.5 | 20,208 | 9.1 | 444 | 23.6 | 6,187 | 11.4 |
| > 120 d | 1,526 | 1.8 | 294 | 1.8 | 643 | 40.4 | 1,356 | 0.6 | 1,299 | 69.1 | 492 | 0.9 |
| Operation type∗ | ||||||||||||
| BCS | 60,120 | 71.8 | 9,402 | 58.8 | 1,085 | 68.2 | 170,933 | 77.2 | 1,173 | 62.4 | 26,803 | 49.4 |
| Mastectomy | 23,634 | 28.2 | 6,593 | 41.2 | 506 | 31.8 | 50,409 | 22.8 | 707 | 37.6 | 27,474 | 50.6 |
| Axillary operation type∗ | ||||||||||||
| None | 36,691 | 43.8 | 4,704 | 29.4 | 168 | 10.6 | 5,382 | 59.3 | 186 | 9.9 | 1,174 | 2.2 |
| SLNB | 22,360 | 26.7 | 5,766 | 36.0 | 916 | 57.6 | 131,306 | 11.5 | 952 | 50.6 | 25,783 | 47.5 |
| SLNB/ALND | 3,353 | 4.0 | 676 | 4.2 | 184 | 11.6 | 25,431 | 11.5 | 292 | 15.5 | 10,514 | 19.4 |
| ALND | 2,649 | 3.2 | 958 | 6.0 | 103 | 6.5 | 12,486 | 5.6 | 130 | 6.9 | 4,519 | 8.3 |
| Unknown | 18,701 | 22.3 | 3,891 | 24.3 | 220 | 13.8 | 46,737 | 21.1 | 320 | 17.0 | 12,287 | 22.6 |
| pT∗ | ||||||||||||
| pT0 | 75,075 | 89.6 | 13,192 | 82.5 | 37 | 2.3 | 660 | 0.3 | 17 | 0.9 | 55 | 0.1 |
| pT1 | 8,246 | 9.8 | 2,619 | 16.4 | 1,308 | 82.2 | 197,252 | 89.1 | 684 | 36.4 | 10,641 | 19.6 |
| pT2 | 351 | 0.4 | 151 | 0.9 | 224 | 14.1 | 2,216 | 10.0 | 1,064 | 56.6 | 40,939 | 75.4 |
| pT3 | 61 | 0.1 | 26 | 0.2 | 20 | 1.3 | 1,080 | 0.5 | 95 | 5.1 | 2,429 | 4.5 |
| pT4 | 11 | 0.0 | 7 | 0.0 | 2 | 0.1 | 134 | 0.1 | 20 | 1.1 | 213 | 0.4 |
| pN∗ | ||||||||||||
| pN0 | 58,328 | 69.6 | 12,539 | 78.4 | 1,182 | 74.3 | 184,293 | 83.3 | 1,138 | 60.5 | 34,653 | 63.8 |
| pN1 | 840 | 1.0 | 285 | 1.8 | 247 | 15.5 | 30,129 | 13.6 | 501 | 26.6 | 15,301 | 28.2 |
| pN2 | 64 | 0.1 | 39 | 0.2 | 21 | 1.3 | 2,422 | 1.1 | 60 | 3.2 | 2,617 | 4.8 |
| pN3 | 37 | 0.0 | 12 | 0.1 | 9 | 0.6 | 695 | 0.3 | 30 | 1.6 | 886 | 1.6 |
| pNx | 24,485 | 29.2 | 3,120 | 19.5 | 132 | 8.3 | 3,803 | 1.7 | 151 | 8.0 | 820 | 1.5 |
| Adjuvant treatment | ||||||||||||
| Endocrine therapy∗ | 43,873 | 52.4 | 979 | 6.1 | 1,591 | 100 | 221,342 | 100 | 1,880 | 100 | 54,277 | 100 |
| Chemotherapy∗ | 1,767 | 2.1 | 1,177 | 7.4 | 177 | 11.1 | 39,749 | 18.0 | 284 | 15.6 | 23,139 | 42.6 |
| Radiation∗ | 45,565 | 54.4 | 8,157 | 51.0 | 849 | 53.4 | 161,328 | 72.9 | 1,052 | 56.0 | 326,680 | 60.2 |
ALND, axillary lymph node dissection; BCS, breast-conserving surgery; DCIS, ductal carcinoma in situ; ER, estrogen receptor; NA, not applicable; NET, neoadjuvant endocrine therapy; pT, pathologic tumor category; pN, pathologic nodal category.
∗
p < 0.05.