Figure 2.

Management approach for advanced ROS1-rearranged (fusion-positive) non-small-cell lung cancer (NSCLC). TKI, tyrosine kinase inhibitor; cfDNA, circulating free DNA; ICI, immune checkpoint inhibitor. *, not preferred and to be used only if other options are not available; must involve multidisciplinary care with neuro-oncology and radiation oncology; **, sensitivity of individual cfDNA next-generation sequencing assay for detection of mutations, fusions and amplifications should be considered.