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. 2020 Jul 20;130(8):4440–4455. doi: 10.1172/JCI131721

Figure 2. Membrane integrity is significantly reduced in proximal and distal muscle in an adoptive transfer model of IIM.

Figure 2

(A) Representative images of IgG-labeled quadriceps from C57BL and Rag1–/– mice receiving adoptive transfer from Foxp3–/Y Syt7–/– mice. Scale bars: 200 μm. (B) Representative images of IgG-labeled EDL from C57BL and from Rag1–/– mice receiving adoptive transfer from Foxp3–/Y Syt7–/– mice. Scale bars: 200 μm. (C) Quantification of quadriceps percentage area positive for IgG (n = 4; ANOVA, F(2,9) = 5.801, P = 0.0241; Tukey’s honestly significant difference [HSD]: C57BL vs. 1 week adoptive transfer, P = 0.0556; C57BL vs. 4 weeks adoptive transfer, P = 0.0294). Data are represented as mean ± SD. (D) Quantification of EDL percentage area positive for IgG (n = 4, 3, and 6 for C57BL, adoptive transfer 1 week, and adoptive transfer 4 weeks, respectively; ANOVA, F(2,10) = 27.77, P < 0.0001; Tukey’s HSD: C57BL vs. 1 week adoptive transfer, P = 0.0006; C57BL vs. 4 weeks adoptive transfer, P < 0.0001). Data are represented as mean ± SD.