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. 2020 Jul 13;130(8):4301–4319. doi: 10.1172/JCI134930

Figure 10. BI-D1870 improves the therapeutic efficacy of radiotherapy in ESCC PDXs.

Figure 10

(A) PDX tumor number 6 treated with the vehicle control, BI-D1870 (50 mg/kg/day, i.p. injection), and/or IR (5 Gy, twice). The growth curve of the tumor size and average tumor weight are presented (n = 6 mice each). (B) IHC analyses of cleaved caspase-3 and Ki-67 in the indicated groups. Scale bars: 100 μm. Data represent the mean ± SD. *P < 0.05 and **P < 0.01. Differences were tested using 1-way ANOVA with Tukey’s post hoc test (A).