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. 2020 Jul 13;130(8):4360–4369. doi: 10.1172/JCI136160

Figure 2. Effect of overexpressing TGF-β isoforms on cone survival.

Figure 2

Schematics of AAV vector design (A) and delivery (B). (C) Representative flat-mounts of FVB (rd1) retinas treated with AAV8-GFP and harvested at P20 or P50. Paired images depict low and high magnifications (boxed areas). Scale bar: 1 mm. (D) Representative flat-mounts of rd1 retinas treated with indicated AAV vectors and harvested at P50. Scale bar: 1 mm. (E) Quantification of GFP-positive cones in central retinas of rd1 mice (n = 12–28) treated with indicated AAV vectors. Data shown are mean ± SEM. **P < 0.01, ****P < 0.0001 by 2-tailed Student’s t test with Bonferroni’s correction.