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. 2020 Jul 13;130(8):4360–4369. doi: 10.1172/JCI136160

Figure 3. Effect of AAV8-TGFB1 on long-term cone survival and cone-mediated vision.

Figure 3

Representative flat-mounts of rd10 (A) and Rho–/– (B) retinas treated with AAV8-GFP or AAV8-GFP plus AAV8-TGFB1. Paired images depict low and high magnifications (boxed areas). Scale bar: 1 mm. (C) Quantification of GFP-positive cones in central retinas of rd10 (n = 18) and Rho–/– (n = 14) mice. (D) Percentage of time spent in dark in a 50:50 light-dark box for untreated animals (n = 8–10) and C3H (rd1) mice (n = 11–14) treated with AAV8-GFP or AAV8-GFP plus AAV8-TGFB1. (E) Visual acuity in eyes from P60 rd10 mice (n = 23) as measured by optomotor after treatment with AAV8-GFP or AAV8-GFP plus AAV8-TGFB1. Data shown are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by 2-tailed Student’s t test for C and E, 2-tailed Student’s t test with Bonferroni’s correction for D.