Skip to main content
. 2020 Jun 29;130(8):4152–4166. doi: 10.1172/JCI134431

Figure 4. Aortic active β-catenin expression increases in aged WT mice and is enhanced by HS diet.

Figure 4

Not β-catenin inhibitor but Wnt inhibitor suppressed salt-induced hypertension and vascular p-MYPT1 expression in HS diet–fed aged WT and heterozygous KL-KO mice. (A) Active β-catenin expression in the aortae of aged WT (left) and KL-KO mice (right) fed NS diet or HS diet, relative to the level in young WT mice. n = 9. *P < 0.05 vs. young WT, aged WT, or KL-KO fed NS diet. (B) Effects of LGK974 (blue) and ICG-001 (orange) on circadian changes in MBP in aged WT (left) and KL-KO mice fed HS diet (right). Right panels show average MBP. n = 4 each. *P < 0.05 vs. HS diet + LGK. (C and D) Effects of ICG-001 (C) and LGK974 (D) on p-MYPT1 expression stimulated by U46619 in the iliac arteries of aged WT and KL-KO mice fed HS diet. (C) Aged WT fed HS diet, n = 7; aged WT fed HS diet + ICG, n = 8; KL-KO fed HS diet and KL-KO fed HS diet + ICG, n = 6 each. (D) Aged WT fed HS diet and aged WT fed HS + LGK, n = 7 each. KL-KO fed HS diet and KL-KO fed HS diet + LGK, n = 8 each. *P < 0.05 vs. HS. Data are means ± SEM. Unpaired t tests were used for comparisons between 2 groups. For multiple comparisons, statistical analysis was performed using the Tukey-Kramer post hoc test. N.S., not significant.