Figure 7. Treatment with Wnt5a antagonist Box5 suppresses salt-induced hypertension and elevation of p-MYPT1 expression in aged WT and heterozygous KL-KO mice.

(A) Effects of Box5 treatment on circadian and average MBP in aged WT (left) and KL-KO mice with HS diet (right). n = 4 each. *P < 0.05 vs. HS diet–fed mice. (B) Effects of Box5 on p-MYPT1 expression stimulated by U46619 in the iliac arteries of aged WT (left) and KL-KO mice with HS diet (right). Aged WT fed HS diet, n = 7; aged WT fed HS diet + Box5, n = 8; KL-KO fed HS diet and KL-KO fed HS diet + Box5, n = 7 each. *P < 0.05 vs. HS diet–fed mice. Data are means ± SEM. Unpaired t tests were performed on comparisons between 2 groups.