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. 2020 Jun 29;130(8):4104–4117. doi: 10.1172/JCI122237

Figure 4. M-3 recovers microvascular function in DIO mice and plasma Aβ42 correlates with microvascular responsiveness.

Figure 4

(A) Plasma Aβ42 levels of DIO mice treated with M-3 or vehicle (n = 8). (B) Endothelium-dependent microvascular responses induced by ACh in vehicle- and M-3–treated DIO mice (n = 9). Quantitative analysis of ACh responses for vehicle- and M-3–treated mice. The broken line denotes the RC-fed WT ACh response. PE, phenylephrine. (C) Endothelium-independent responses induced by SNP in vehicle- and M-3–treated DIO mice (n = 8). Quantitative analysis of SNP responses for vehicle- and M-3–treated mice. The broken line denotes the RC-fed WT SNP response. Linear regression between plasma Aβ42 levels and ACh (D) and SNP (E) responses for experimental groups of mice. Data are means ± SEM. **P < 0.01, ***P < 0.001 by 2-tailed unpaired Student’s t test.