Table 7.

Continued

	Sample Size (Eyes)
Study	KC Group	Control Group	Technology Used and Degree of KC Detected/Classified	Total Parameters Considered/Best Parameters Used	Area Under Curve	Sensitivity (%)	Specificity (%)
Rabinowitz et al. (2014)33	46 moderate 54 early 7 FFKC 16 suspect	180	TMS-4 videokeratographer, RTVue Fourier-domain OCT, and Hartmann–Shack aberrometer Detects and classifies normal, FFKC, and suspect, early, and moderate KC	A combination of videokeratography and OCT indices (I-S value and minimum pachymetry) and PA/I-S	Not mentioned	Moderate, 100 Early, 100 FFKC, 100 Suspect, 63	Moderate, 100 Early, 100 FFKC, 97 Suspect, 98
Silverman et al. (2017)34	30	111	Pentacam Scheimpflug tomography and Artemis very-high-frequency ultrasound Detects clinical KC	105 Artemis and 96 Pentacam variables Combination of 3 Artemis and 4 Pentacam parameters	>0.99	97	100
Yousefi et al. (2018)35	796 FFKC 390 KC	1970	Casia OCT Detects FFKC (early) and KC (mild) Four clusters according to the Casia ESI and diagnostic labeling convention	420 parameters 2 eigen parameters	Not mentioned	N vs. KC, 97	N vs. KC, 96

CDVA, corrected distance visual acuity; ESI, ectasia status index; FFKC, forme fruste keratoconus; I-S, inferior–superior keratometric difference; KC, keratoconus; MCT, minimum corneal thickness; N, normal; OCT, optical coherence tomography; PA/I-S, pachymetry/asymmetry index; RETICS, Thematic Network for Co-Operative Research in Health; SD-OCT, spectral-domain optical coherence tomography.