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CDK5-centered regulatory network and its involvement in human neurodevelopmental disorders. PAFAH1B1 (aka LIS1) and YWHAE bind to CDK5/p35-phosphorylated NUDEL, thereby protecting it from degradation. Two other proteins involved in lissencephalic syndromes, DCX and NDE1 (aka LISX1 and LIS4, respectively), are also phosphorylated and regulated by CDK5, which thus plays a central role in the neuronal development mechanisms underlying lissencephaly
