Fig. 4.

Edgotyping disease-causing protein variants. a left: a wild-type protein (red) interacts with 5 different proteins; middle: all interactions are lost because the protein is no longer expressed (gene deletion, nonsense or frameshift mutations causing mRNA NMD), or its structure is severely compromised (all kinds of mutations); right: only one of the interactions is lost (truncation-inducing or missense mutation). b Edgotyping of the CDK6 A197T variant, which is suspected to retain its enzymatic activity but which no longer localizes in the centrosomes because of a hypothetic loss of interaction with a centrosomal protein that remains to be identified