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. 2020 Aug 6;21(1):96. doi: 10.1186/s10194-020-01161-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Changes in spontaneous and input-evoked activity of TCC neurons after CCI-IoN. (a) Frequency of spontaneous discharges increased four-fold in CCI-IoN animals (C, control group; CCI, CCI-IoN group). (b) Representative PSTHs of vibrissal responses (50 stimuli) in a control case (upper plot) and in a CCI-IoN rat (lower plot). Insets show raw data examples; arrowheads indicate stimulus onset. The response was higher in the CCI-IoN rat. (c) Plot of the mean vibrissal response in control and in CCI-IoN animals. The response was greater in CCI-IoN animals. (d) The response to GON stimulation did not differ significantly between control and CCI-IoN animals. V-C, vibrissal response in control animals; V-CCI, vibrissal response in CCI-IoN animals; N-C, GON response in control animals; N-CCI, GON response in CCI-IoN animals; * p < 0.05; *** p < 0.0001