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. 2020 Aug 6;21(1):96. doi: 10.1186/s10194-020-01161-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effect of GON stimulation on vibrissal responses in control (blue) and CCI-IoN (magenta) animals. (a) An example of raw recordings during vibrissal stimulation alone (upper trace) or preceded by GON stimulation (lower trace). (b) Representative PSTHs in a control case (upper plot) and a CCI-IoN case (lower plot). Plots on the left show the response to vibrissal stimulation (arrowheads) alone. On the right, responses to vibrissal stimulation (arrowheads) when preceded by GON stimulation (vertical arrow) are illustrated. In the control case (top) GON stimulation facilitated vibrissal response, whereas the opposite occurred in the CCI-IoN. (c) Top, same-case comparisons between vibrissal responses alone (V, empty circles) and when preceded by GON stimulation (N + V, 100 ms delay; filled circles) in control (blue traces) and CCI-IoN animals (red traces). Bottom, mean (+sem) vibrissal responses from the data above. GON stimulation facilitated vibrissal response in control animals but inhibited vibrissal responses in CCI-IoN animals. *** p < 0.0001