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. 2020 Aug 6;21(1):96. doi: 10.1186/s10194-020-01161-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — (a) Simplified sketch of the neuronal discharges in TCC following vibrissal stimulation (black horizontal bars; magenta vertical bars) and GON stimulation (arrowheads; blue vertical bars). Gray vertical bars indicate the resting, spontaneous discharge of the same TCC units studied after vibrissal stimuli. For better visualization, spontaneous and evoked responses are represented at different time scales (spontaneous activity compressed 10x; interstimulus interval, stimulus duration and firing responses expanded 3-5x). The bottom recordings show the effect of a conditioning GON stimuli on the following response to facial stimuli. (b) Similar sketch summarizing the effects of blocking inhibitory GABAergic (Bic), Glycinergic (Str) or both GABA- and Glycinergic transmission (Bic + Str) on the conditioning effect of GON stimulation on the response to vibrissal stimulation. The number of vertical bars under each of these three conditions represent comparisons with the values observed just prior to the application of the drug(s) shown in (a). (c) Simplified view of a minimal local circuitry in laminae III of TCC that could help explain, at a circuital level only, the effects of GON stimulation on the successive response of TCC units to light stimulation of the vibrissal pad under control or CCI-IoN conditions. Units responding to GON could be different (R1, more likely) or the same (R2, less likely) units recorded after vibrissal stimulation. Color codes and geometric figures identify different excitatory and inhibitory neurons and synapses. Other possible excitatory neurons interposed in the circuit are omitted