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. 2020 Aug 6;12:119. doi: 10.1186/s13148-020-00907-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Transcriptional silencing of immune pathways by promoter hypermethylation in nonresponders. a Fraction of enriched hypermethylated (left) and under-expressed immune pathways (right) in nonresponders and responders. The number of the pathways showing significant enrichment (FDR < 0.1) by GSEA is indicated above the bars. b Relationship between enriched hypermethylated and under-expressed immune pathways in nonresponders. The significance of overlap was determined by Fisher’s exact test. c Representative GSEA plots of the overlapped pathways