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. 2020 Aug 6;12:119. doi: 10.1186/s13148-020-00907-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Risk score calculated by Lasso Cox regression models and survival analysis in three different cohorts. a Training set (n = 60; our cohort). b IDIBELL set (n = 81). c–d TCGA high- (n = 151) and low-immune pressure cohorts (n = 259). Patients in the TCGA cohort were divided into high- and low-TIL cohorts according to mean value of tumor infiltrating lymphocyte (TIL) fraction. Kaplan-Meier survival analyses of the patients are displayed on the top. The patients in each cohort were divided into low- and high-risk groups based on mean of risk index produced by our model (i.e., mean score). P values were calculated using the log-rank test. The methylation levels of the eight genes included in our model are shown as a heatmap on the bottom. Methylation values were z score normalized per gene. Genes (x-axis) and samples (y-axis) are ordered in increasing order of coefficient and risk score, respectively. Methylation probe for CTSD gene selected by our model is not present in TCGA cohort