Table 1.

Genes used in methylation-based prognostic prediction model

Probe	Coefficient	Gene symbol	Gene function	Cancer relatedness
cg22029157	− 1.52	IRF6	Interferon regulatory factor associated with cytokine signaling	Tumor suppressor activity
cg12007048	− 1.096	CTSD	Proteolytic activation of hormones and growth factors (i.e., EGFR)	Linked with poor prognosis in NSCLC
cg07935119	− 1.04	GRN	Granulin coding gene; growth factor involved in inflammation and cell proliferation	Regulate tumorigenesis; immune evasion, proliferation
cg23079808	− 0.989	LTBR	Tumor necrosis factor receptor; signaling immune response and programmed cell death	Activation linked to carcinogenesis
cg04450862	− 0.907	TRIM36	Mediate ubiquitination and proteasomal degradation of target protein	Known to be upregulated in cancer
cg19918549	0.347	EVL	Actin-associated proteins involved in axon guidance	Upregulated in breast cancer
cg24612198	0.385	CD3E	Part of CD3 complex that facilitate T cell development	Down regulation of this gene results in T cell apoptosis
cg17771150	0.969	LCP1	Actin-binding protein that are involved in T cell activation	Upregulated in cancer