Table 3. Comparison of responders and non-responders to decitabine.
| Responders (CR, CRi or PR, n = 27) | Non-responders (n = 69) | Total (n = 96) | P-value | |
|---|---|---|---|---|
| Age, years | .059 | |||
| Median (Range) | 71.7 (67−87) | 75.0 (65−91) | 73.9 (65−91) | |
| Sex | .022* | |||
| Male | 21 (77.8%) | 36 (52.2%) | 57 (59.4%) | |
| Eastern Cooperative Oncology Group (ECOG) performance status | .349 | |||
| 0−1 | 15 (55.6%) | 31 (44.9%) | 46 (47.9%) | |
| 2−4 | 12 (44.4%) | 38 (55.1%) | 50 (52.1%) | |
| Body mass index (BMI) | .907 | |||
| Median (Range) | 22.7 (18.5−29.7) | 23.3 (16.3−32.2) | 23.2 (16.3−32.2) | |
| Mini nutritional assessment short from (MNA-SF) score | .353 | |||
| Median (Range) | 10 (4−13) | 9 (4−13) | 9 (4−13) | |
| World Health Organization (WHO) classification | .671 | |||
| AML with recurrent genetic abnormalities | 4 (14.8%) | 6 (8.7%) | 10 (10.4%) | |
| AML with myelodysplasia-related changes | 8 (29.6%) | 16 (23.2%) | 24 (25.0%) | |
| Therapy-related myeloid neoplasms | 1 (3.7%) | 4 (5.8%) | 5 (5.2%) | |
| AML, NOS | 14 (51.9%) | 43 (62.3%) | 57 (59.4%) | |
| Risk groups | .227 | |||
| Favorable | 3 (11.1%) | 6 (8.7%) | 9 (9.4%) | |
| Intermediate | 21 (77.8%) | 44 (63.8%) | 65 (67.7%) | |
| Poor | 3 (11.1%) | 19 (27.5%) | 22 (22.9%) | |
| Bone marrow (BM) blasts | .015* | |||
| Median (Range) | 43% (20−90) | 62% (20−97) | 56% (20−97) | |
| Peripheral blood (PB) blasts | ||||
| Present | 12 (44.4%) | 48 (69.6%) | 60 (62.5%) | .022* |
| Median (Range) | 0% (0−84%) | 10% (0−92%) | 7% (0−92%) | .204 |
| White blood cells, 109/L | .216 | |||
| Median (Range) | 2.89 (0.83−87.99) | 4.12 (0.51−176.44) | 3.87 (0.51−176.44) | |
| Hemoglobin, g/dL | .757 | |||
| Median (Range) | 8.5 (4.7−11.4) | 8.2 (3.5−11.9) | 8.3 (3.5−11.9) | |
| Platelet, 103/mm3 | .248 | |||
| Median (Range) | 56 (10−180) | 61 (1−945) | 58 (1−945) | |
| Albumin, g/dL | .010* | |||
| Median (Range) | 3.9 (3.0−4.8) | 3.7 (2.3−4.7) | 3.7 (2.3−4.8) | |
| Creatinine, mg/dL | .701 | |||
| Median (Range) | 1.15 (0.5−1.81) | 0.92 (0.4−4.9) | 1.0 (0.4−4.9) | |
| CRP, mg/dL | .004* | |||
| Median (Range) | 0.68 (0.03−21.43) | 2.62 (0.05−62.5) | 1.75 (0.03−62.5) | |
| Ferritin, ng/mL | .547 | |||
| Median (Range) | 585 (80−7803) | 585 (90−>10000) | 585 (80−>10000) | |
*Statistically significant P values are shown in bold.