Figure. 1.

Ketamine 8 mg/kg is rapidly absorbed in the brain and does not induce side effects. (A) Pharmacokinetic analysis of total ketamine concentration in plasma (left) and brain (right) in WT adult mice after a single intraperitoneal injection (n = 3 mice per time point). (B) A single dose of ketamine 8 mg/kg did not affect spontaneous locomotor activity (Two-way ANOVA, p ≥ 0.05. Empty square: WT-saline, n = 6 mice; gray square: WT-ketamine, n = 15 mice) (C) High dose of ketamine (56 mg/kg) significantly reduced PPI response (Kruskal-Wallis, ** p ≤ 0.01, Dunn’s post-test. WT–saline, n = 10; WT-ketamine 8 mg/kg, n = 10; WT-ketamine 56 mg/kg, n = 8 mice).