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. Author manuscript; available in PMC: 2020 Aug 6.
Published in final edited form as: Biol Psychiatry. 2015 Aug 24;79(9):755–764. doi: 10.1016/j.biopsych.2015.08.018

Table 1.

Mouse pharmacokinetic parameters after 8 mg/kg i.p. administration of ketamine.

Cmax (ng/mL) V (L) AUCinf (ng.h/L) t1/2,α (h) t1/2,β (h) CLd (L/h) CL (L/h) B/P ratio
P15 463 ± 87 115 ± 38 122 ± 26 0.05 ± 0.03 0.28 ± 0.17 157 ± 78 71 ± 12 14.7 ± 1
P30 1760 ± 231 81 ± 12 296 ± 48 0.09 ± 0.03 0.25 ± 0.13 284 ± 86 30 ± 7.2 8.7 ± 3.7
Adults 1209 ± 152.5 69 ± 4 366 ± 59 0.07 ± 0.01 1.11 ± 0.8 326 ± 51 48 ± 3 2.7 ± 0.5

Cmax : maximum concentration, V: volume of distribution, AUCinf: area under the concentration time curve (AUC) with the last concentration extrapolated based on the elimination rate constant, t1/2,α: distribution of half-life, t1/2,β: elimination half-life, CLd: distribution clearance, CL: systemic clearance, B/P: brain to plasma ratio. Data are expressed as mean ± SEM.