Table 1.
Serum and CSF parameters at indicated time points before and after ART initiation
| Pre-ART initiation* | Post-ART initiation | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Date | October 15, 2017 | October 21, 2017 | October 24, 2017 | October 26, 2017 | October 28, 2017 | February 9, 2018 | June 11, 2018 | June 22, 2018 | June 27, 2018 | August 29, 2018 |
| CD4 (cells/μL) | < 20 | 40 | 35 | 46 | ||||||
| CD4 (%) | 1 | 6 | 7 | 6 | ||||||
| LP OP (cm H2O) | 24 | 50 | 36 | 47 | 39 | – | – | 29 | 32 | – |
| CSF WBC (per cumm) | 2 | 5 | 3 | 0 | 12 | 96 | 72 | 187 | 127 | 1900 |
| CSF neut (%) | 3 | 12 | 5 | – | 0 | 21 | 25 | 65 | 52 | 74 |
| CSF lymph (%) | 61 | 65 | 39 | – | 43 | 70 | 67 | 25 | 34 | 16 |
| CSF total protein (mg/dL) | 36 | 34 | 27 | 33 | 28 | 620 | 620 | 620 | 620 | 620 |
| CSF glucose (mg/dL) | 13 | 17 | 20 | 19 | 24 | 10 | 35 | 41 | 39 | 10 |
| CSF CrAg titer | 1:2,560 | 1:2,560 | 1:2,560 | 1:2,560 | 1:2,560 | 1:2,560 | 1:2,560 | 1:2,560 | – | 1:2,560 |
| C. neo. PCR | Positive | – | – | – | – | Negative | Negative | – | – | Negative |
| CSF Gram stain | Moderate C. neo. | Moderate C. neo. | Moderate C. neo. | Moderate C. neo. | Rare C. neo. | Moderate C. neo. | Negative | Negative | Negative | Negative |
| CSF fungal culture | C. neo. | Negative | C. neo. | – | C. neo | Negative | Negative | Negative | Negative | Negative |
ART = anti-retroviral therapy; C. neo = Cryptococcus neoformans; CSF = cerebrospinal fluid; OP = opening pressure.
*
Anti-retroviral therapy initiation November 9, 2017.