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. 2020 Aug 6;9:e57381. doi: 10.7554/eLife.57381

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© 2020, Yoshida et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 10. — (Left panel) A schematic model of normal ciliogenesis and response to stimulation with Hh ligand. (Right panel) A schematic model ciliogenesis and response to stimulation with Hh ligand in Dyrk2-deletion. The morphology of primary cilia in Dyrk2^-/- MEFs was elongated and often bulged at the tips. In Dyrk2^-/- cells, downregulation of Aurka and other ciliary disassembly genes caused suppression of disassembly and elongation of primary cilia. Furthermore, abnormal ciliary trafficking caused accumulation of GLI2, GLI3, and SuFu in Dyrk2^-/- cells. Consequently, the induction of Hh signaling is drastically suppressed by deletion of Dyrk2.