Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 31;16:1863–1877. doi: 10.2147/NDT.S260748

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Bu et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

ATC-derived exosomes reduce I/R-induced neurological damage in rats. (A) After the injection of 30 μg/mL Exo in the I/R group, the neurological deficit score was used to evaluate the effects of ATC-derived exosomes on neurocognitive function in rats. (B) TTC staining was used to calculate the cerebral infarct size in rats treated with exosomes. (C) The degree of cerebral edema was detected in rats treated with exosomes. (D) Nissl staining was used to detect the number of Nissl’s body in rat brain tissue. (E) Detection of nerve activity in rats in each group by c-fos immunohistochemistry. (F) Detection of neuronal apoptosis in rats in each group by TUNEL. All experiments were performed three individual times; Data are expressed as mean ± standard deviation. One-way ANOVA and Tukey’s multiple comparison test were used to determine statistical significance. *P < 0.05, **P < 0.01 vs the Sham group; ^#P < 0.05 vs the I/R group.

Abbreviations: ANOVA, analysis of variance; ATC, astrocyte; Exo, exosome; I/R, ischemic-reperfusion; TTC, 2,3,5-triphenyltetrazole chloride; TUNEL, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling.