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. 2020 Jul 31;16:1863–1877. doi: 10.2147/NDT.S260748

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© 2020 Bu et al.

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ATC-derived exosomal miR-361 downregulates AMPK/mTOR signaling pathway by targeting CTSB. (A, B) Detection of mRNA and protein levels of AMPK and mTOR in rat brain tissue by RT-qPCR and Western blot analysis, respectively. (C, D) Detection of mRNA and protein levels of AMPK and mTOR in PC12 cells by RT-qPCR and Western blot analysis, respectively. All experiments were performed three individual times; Data are expressed as mean ± standard deviation. One-way ANOVA and Tukey’s multiple comparison test were used to determine statistical significance, while in panel B and D, two-way ANOVA was used. N = 3; * compares to the Sham or Control group; # compares to I/R or OGD/R group; @ compares to Empty or OGD/R-Empty group. *P < 0.05, ^#P < 0.05, ^@P < 0.05.

Abbreviations: AMPK/mTOR, AMP-activated protein kinase/mammalian target of rapamycin; ANOVA, analysis of variance; ATC, astrocyte; CTSB, cathepsin B; Exo, exosome; I/R, ischemic-reperfusion; miR, microRNA; OGD/R, oxygen-glucose deprivation/reoxygenation; RT-qPCR, reverse transcription-quantitative polymerase chain reaction.