Table 2:

Brain atrophy measures of the study subjects between index and postindex, according to MRI changes^a

	Total Patients with RRMS	Patients with RRMS with MRI Software/Coil/Protocol Changes	Patients with RRMS without MRI Software/Coil/Protocol Changes	P Valueb
PBVC on 2D-T1WI	n = 259	n = 89	n = 170	.233
	−0.31 (−0.74–0.13)	−0.35 (−0.97–0.11)	−0.28 (−0.67–0.14)
PBVC on 3D-T1WI	n = 110	n = 37	n = 73	.740
	−0.38 (−0.88 to −0.04)	−0.38 (−0.93–0.02)	−0.37 (−0.81 to −0.08)
PLVVC on 2D-T1WI	n = 257	n = 89	n = 168	.848
	0.95 (−1.77–3.99)	0.95 (−1.92–4.1)	0.96 (−1.63–3.94)
PLVVC on 3D-T1WI	n = 110	n = 37	n = 73	.940
	1.47 (−1.26–4.39)	1.5 (−1.36–4.15)	1.01 (−1.17–4.46)
PLVVC on T2-FLAIR	n = 388	n = 130	n = 258	.179
	0.90 (−2.91–5.94)	0.21 (−4.67–7.2)	1.1 (−2.1–5.51)
PLVVC on T2-FLAIRc	n = 554	n = 291	n = 263	.007
	0.51 (−3.95–6.01)	−0.31 (−6.4–6.9)	1.13 (−2.15–5.53)

^aPBVC and PLVVC on 2D-, 3D-T1WI and T2-FLAIR were obtained in patients with software/coil/protocol scanner changes. All values in the table are presented as the number of patients for a particular analysis, median, and interquartile range. The longitudinal follow-up values are annualized.

^bP values represent patients with MS with and without MRI changes during the follow-up group comparisons and were derived using analysis of covariance adjusted for age, sex, days between index and postindex, and baseline volume as appropriate.

^cPLVVC on T2-FLAIR was performed in patients with hardware/software/coil/protocol changes.