Table 5:

Results of regression tree predictions to make prediction of total ALSFRS-R score at 1 year after MRI with several clinical and MRI predictors^a

Predictors	Coefficient of Determination R2 (Best Value = 1.0)	Mean Squared Error (Best Value = 0.0)
Clinical predictors	0.54	41.87
Clinical predictors + SCCSA	0.72	25.39
Clinical predictors + GMCSA + WMCSA/GMCSA	0.74	23.77

Note:—WMCSA indicates white matter cross-sectional area.

^aGMCSA, WMCSA, and SCCSA are averaged across the C4–C6 vertebral levels. Clinical predictors include age, body mass index, sex, site of onset, delay between first symptoms and diagnosis, total ALSFRS-R score at baseline, and total ALSFRS-R score progression rate at baseline.