Table 2:
Sensitivity, specificity, and positive and negative predictive values in patients using method C as the reference for detection of leptomeningeal contrast-enhancement focia
| Sensitivity | Specificity | PPV | NPV | P Value | |
|---|---|---|---|---|---|
| Total study sample | |||||
| Method A LM CE presence | 89.8% (74.8–96.7) | 92.7% (88.2–95.6) | 68.6% (53.9–80.5) | 98.1% (94.8–99.4) | <.001b |
| Method B LM CE presence | 84.6% (68.8–93.6) | 97.3% (93.8–98.8) | 84.6% (68.8–93.6) | 97.3% (93.9–98.9) | <.001b |
| CIS-only sample | |||||
| Method A LM CE presence | 100% (5.5–100) | 82.3% (62.1–99.6) | 50% (2.7–97.3) | 100% (69.9–100) | .143 |
| Method B LM CE presence | 100% (5.5–100) | 100% (71.6–100) | 100% (54.7–97.2) | 100% (71.6–100) | .071 |
| RR-only sample | |||||
| Method A LM CE presence | 90.1% (74.5–97.6) | 92.2% (86.9–95.5) | 68.2% (52.3–80.9) | 98.2% (94.5–99.5) | <.001b |
| Method B LM CE presence | 87.9% (70.9–96.0) | 96.7% (92.5–98.6) | 82.9% (65.7–92.8) | 97.7% (93.9–99.3) | <.001b |
| SP-only sample | |||||
| Method A LM CE presence | 96.3% (79.1–99.8) | 96.3% (79.1–99.8) | 80% (29.9–98.9) | 96.3% (79.1–99.8) | <.001b |
| Method B LM CE presence | 60% (17.0–92.7) | 100% (84.9–100) | 100% (30.9–100) | 93.1% (75.7–98.7) | .002 |
a
Method A assessment was performed using postcontrast 3D-FLAIR images in native space; method B, using pre- and postcontrast 3D-FLAIR images in native space; and method C, using the coregistered, pre-/postcontrast 3D-FLAIR subtracted images. Data are presented as sensitivity, specificity, PPV, and NPV. In parenthesis are 95% confidence intervals. P Value refers to the significance of the contingency table (Fisher exact test).
b
Significant.