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. 2020 Jun 25;39(32):5455–5467. doi: 10.1038/s41388-020-1376-3

Fig. 2. NeoGATA3-mutant tumors do not display a prominent immune response.

Fig. 2

a Gene expression levels in tumors of the METABRIC ER + cohort, divided in the three groups according to GATA3 status (WT n = 1189, neoGATA3 n = 66, OtherMut n = 155). b MCP counter scores for the indicated immune cell populations in the three groups of METABRIC ER + tumors (WT n = 1205, neoGATA3 n = 65, OtherMut n = 161). c Representative IHC images of CD8α-positive cells in one tumor with wt GATA3 and in one with neoGATA3. Quantification of the staining of WT (n = 6) and neoGATA3 (n = 9) tumors is shown under the microphotographs. Mann–Whitney U test was used in (a, b), two-sided Student’s t test was used in (c) *P < 0.05, **P < 0.01.