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. 2020 Jul 31;11:1716. doi: 10.3389/fmicb.2020.01716

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Copyright © 2020 Kumar, Vijaykumar, Dikhit, Abhishek, Mukherjee, Sen, Das and Das.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prediction and validation of TGFBR as target gene of miRNA-93-5p. (A) Schematic representation of miRNA-93-5p sequence bound to TGFBR receptor. The luciferase constructs fused to 30 untranslated regions (UTRs) (or Mut) of TGFB receptor were cotransfected in macrophages cells with mimic miRNA-93 or mimic-NC. The luciferase activities were expressed as the ratio of firefly luciferase over renilla luciferase. (B) The macrophages transfected with mimic of miRNA-93 significantly reduced the luciferase activities (P < 0.001) of genes fused to the TGFB receptor family 30 UTR. (C) Effect of antagomir miRNA-93-5p in the activation of interleukin (IL)-10/IL-12 secretion from macrophages after infection.