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. 2020 Jul 30;7(3):473–516. doi: 10.1007/s40744-020-00219-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — The classical (or cis-) and trans-signaling pathways of IL-6. gp130 glycoprotein 130, IL-6 interleukin-6, IL-6Rα interleukin-6 receptor alpha, JAK Janus kinase, MAPK mitogen-activated protein kinase, P phosphate, SOCS3 suppressor of cytokine signaling 3, STAT3 signal transducer and activator of transcription 3, Y tyrosine