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. 2020 Jul 31;10:1185. doi: 10.3389/fonc.2020.01185

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Copyright © 2020 Drury, Rychahou, He, Jafari, Wang, Lee, Weiss, Evers and Zaytseva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of CD36 is associated with decreased cellular proliferation. (A) Primary Pt 93 and Pt 130 CRC cells treated with 100 μM SSO for 6 days. Cellular proliferation assays were performed via cell count. Representative data from three experiments is shown (*p < 0.05). (B) Confocal images of FASN and CD36 in Pt 93 cells in normal and serum free media (6 days). (C) Expression of proteins associated with apoptosis and survival in HCT116 transfected with CD36 shRNAs and analyzed via western blot. (D) Cellular proliferation assay with HCT116, NTC, and CD36 shRNA (*p < 0.05 for normal medium, ^#p < for SFM). (E) qRT-PCR confirmation of CD36 knockdown using CD36 shRNA #2 (73%) and CD36 shRNA #4 (67%).