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. 2020 Aug 6;10:13190. doi: 10.1038/s41598-020-69927-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Exclusion of individuals above (left panel) and below (right panel) a z-score threshold (horizontal axis) with resulting group prevalence shown on the vertical axis. The left panel shows risk reduction in a low PRS population, the right panel shows risk enhancement in a high PRS population. Top figures are results in the general population, bottom figures are the Affected Sibling Pair (ASP) population (i.e., variation of risk with PRS among individuals with an affected sib). Phenotype is Heart Attack.This plot was made using pyplot v3.2.1 under license https://matplotlib.org/3.2.1/users/license.html.