Table 1.
Polygenic predictors tested on sibling pairs.
| Condition | N pairs (single case) | Sibling case higher PRS fraction | Random case higher PRS fraction |
|---|---|---|---|
| Asthma | 3,948 | 0.618 (0.004) | 0.633 (0.005) |
| Atrial fibrillation | 332 | 0.620 (0.033) | 0.636 (0.013) |
| Basal cell carcinoma | 431 | 0.599 (0.014) | 0.616 (0.009) |
| Breast cancer (LASSO-L1) | 583 | 0.585 (0.020) | 0.586 (0.014) |
| Breast cancer (Khera) | 583 | 0.557 (–) | 0.601 (–) |
| Coronary artery disease (LASSO-L1) | 1,072 | 0.556 (0.012) | 0.579 (0.017) |
| Coronary artery disease (Khera) | 1,073 | 0.596 (–) | 0.614 (–) |
| Gallstones | 700 | 0.592 (0.006) | 0.622 (0.014) |
| Glaucoma | 440 | 0.593 (0.013) | 0.602 (0.015) |
| Gout | 631 | 0.627 (0.007) | 0.661 (0.003) |
| Heart attack | 900 | 0.593 (0.012) | 0.603 (0.006) |
| High cholesterol | 4,291 | 0.596 (0.005) | 0.632 (0.002) |
| Hypothyroidism | 2,031 | 0.658 (0.003) | 0.699 (0.005) |
| Hypertension | 6,931 | 0.627 (0.002) | 0.645 (0.001) |
| Malignant melanoma | 360 | 0.547 (0.040) | 0.592 (0.013) |
| Prostate cancer | 106 | 0.642 (0.015) | 0.650 (0.034) |
| Testicular cancer | 24 | 0.575 (0.090) | 0.607 (0.133) |
| Type 1 diabetes | 290 | 0.646 (0.019) | 0.669 (0.006) |
| Type 2 diabetes | 1,594 | 0.595 (0.005) | 0.620 (0.001) |
The first column is the number of sibling pairs with one affected and one unaffected sibling. The second column is the average and standard deviation (over five predictors) of the fraction in which the case has higher PRS. Third column gives results for non-sibling (random) pairs. Quantities in bold have uncertainties in the central value larger than 10% due to low statistics.