Table 2.

Predictors tested on sibling pairs with a single case, where one sibling is high risk ($+1.5$, $+2$, $+2.5$ SD or 93rd, 97.5th, 99th percentile) and the other is normal risk ($<+1$ SD or < 85th percentile).

Condition	N pairs	1 sib 93rd	N	1 sib 97th	N	1 sib 99th
Asthma	402	0.758 (0.021)	110	0.782 (0.039)	17	0.882 (0.078)
Atrial fibrillation	37	0.757 (0.071)	20	0.750 (0.097)	9	1.0 (–)
Basal cell carcinoma	54	0.648 (0.065)	23	0.826 (0.079)	6	0.667 (0.192)
Breast cancer (LASSO-L1)	45	0.662 (0.071)	11	0.545 (0.150)	2	0.5 (0.353)
Breast cancer (Khera)	52	0.596 (0.068)	12	0.583 (0.142)	3	0.667 (0.272)
Coronary artery disease (LASSO-L1)	131	0.613 (0.043)	48	0.424 (0.071)	10	0.5 (0.158)
Coronary artery disease (Khera)	109	0.706 (0.044)	38	0.816 (0.063)	5	0.800 (0.179)
Gallstones	212	0.720 0.031	158	0.697 (0.037)	85	0.686 (0.050)
Glaucoma	30	0.720 (0.082)	9	0.667 (0.157)	1	–
Gout	70	0.743 (0.052)	37	0.784 (0.068)	16	0.875 (0.083)
Heart attack	68	0.685 (0.056)	16	0.688 (0.116)	4	–
High cholesterol	441	0.660 (0.023)	130	0.662 (0.042)	28	0.786 (0.078)
Hypothyroidism	282	0.780 (0.025)	109	0.890 (0.030)	32	0.906 (0.052)
Hypertension	757	0.726 (0.016)	229	0.777 (0.027)	53	0.811 (0.054)
Malignant melanoma	30	0.600 (0.089)	10	0.600 (0.155)	2	1.0 –
Prostate cancer	8	0.875 (0.117)	0	–	0	–
Testicular cancer	0	–	0	–	0	–
Type 1 diabetes	41	0.805 (0.062)	28	0.893 (0.058)	17	0.824 (0.092)
Type 2 diabetes	137	0.772 (0.036)	37	0.816 (0.064)	8	0.75 (0.153)

The first column is the number of pairs used. The second column is the fraction of pairs where the high risk sibling is the case. 1 SD binomial errors given in parenthesis. Quantities in bold have uncertainties in the central value larger than 10% due to low statistics.