Table 3.
Predictors tested on non-sibling (random) pairs w/ a single case where one is high risk (, , SD above or 93rd, 97.5th, 99th percentile) and the other is normal risk ( Standard Deviation or < 85th percentile).
| Condition | N pairs | 1 sib 93rd | N | 1 sib 97th | N | 1 sib 99th |
|---|---|---|---|---|---|---|
| Asthma | 777 | 0.749 (0.016) | 289 | 0.794 (0.026) | 72 | 0.889 (0.050) |
| Atrial fibrillation | 76 | 0.734 (0.057) | 44 | 0.723 (0.079) | 24 | 0.783 (0.108) |
| Basal cell carcinoma | 65 | 0.708 (0.067) | 34 | 0.706 (0.098) | 9 | 0.889 (0.211) |
| Breast cancer (LASSO-L1) | 132 | 0.638 (0.050) | 50 | 0.720 (0.077) | 10 | 0.800 (0.205) |
| Breast cancer (Khera) | 143 | 0.678 (0.044) | 60 | 0.683 (0.071) | 23 | 0.696 (0.124) |
| Coronary artery disease (LASSO-L1) | 117 | 0.634 (0.054) | 40 | 0.640 (0.092) | 7 | 0.429 (0.247) |
| Coronary artery disease (Khera) | 187 | 0.711 (0.037) | 78 | 0.719 (0.060) | 22 | 0.773 (0.124) |
| Gallstones | 210 | 0.695 (0.035) | 149 | 0.718 (0.041) | 65 | 0.723 (0.066) |
| Glaucoma | 42 | 0.757 (0.079) | 16 | 0.788 (0.125) | 3 | 1.0 (0.457) |
| Gout | 115 | 0.852 (0.041) | 69 | 0.870 (0.054) | 40 | 0.850 (0.078) |
| Heart attack | 121 | 0.645 (0.048) | 45 | 0.622 (0.085) | 14 | 0.571 (0.166) |
| High cholesterol | 881 | 0.712 (0.016) | 340 | 0.738 (0.026) | 108 | 0.769 (0.048) |
| Hypothyroidism | 505 | 0.844 (0.018) | 240 | 0.879 (0.025) | 79 | 0.911 (0.044) |
| Hypertension | 1883 | 0.755 (0.010) | 727 | 0.812 (0.016) | 222 | 0.820 (0.029) |
| Malignant melanoma | 64 | 0.597 (0.078) | 29 | 0.655 (0.109) | 17 | 0.706 (0.149) |
| Prostate cancer | 37 | 0.784 (0.089) | 12 | 0.750 (0.184) | 9 | 0.778 (0.221) |
| Testicular cancer | – | – | – | – | – | – |
| Type 1 diabetes | 86 | 0.849 (0.049) | 56 | 0.911 (0.056) | 35 | 0.914 (0.076) |
| Type 2 diabetes | 230 | 0.764 (0.030) | 75 | 0.853 (0.052) | 23 | 0.870 (0.110) |
The first column is the number of pairs. The second column is the fraction of pairs where the high risk individual is the case. 1 SD binomial errors given in parenthesis. Quantities in bold have uncertainties in the central value larger than 10% due to low statistics.