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. 2020 Aug 6;10:13303. doi: 10.1038/s41598-020-70145-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The M. genitalium whole-cell biochemical network an topological analysis. a number of molecules per functional group in logarithmic scale. b Number of reactions per cellular process in logarithmic scale. c Graphical visualization of the M. genitalium whole-cell network. Edges with high associated stoichiometry (over 100) are hidden for better visualization. The big circular group on the right is mainly composed by DNA-Protein complexes and their respective formation reactions. d Number of molecules per compartment in logarithmic scale. e Degree distribution of molecule nodes. The subgraph in the figure is the same degree distribution but showing only the protein and metabolite subgroups of nodes. f Degree distribution for reaction nodes where de degree is the number of connections solely. g Distribution of number of processes a given molecule node participates. h Spearman correlation between node degree and number of processes for all molecule nodes. i Spearman correlation between node degree and number of processes for only proteins and metabolites.