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. 2020 Jul 31;8:701. doi: 10.3389/fcell.2020.00701

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Copyright © 2020 Scott and Campos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model: Histone dynamics at the replication fork. The replication machinery encounters nucleosomes as it progresses. As this occurs, the MCM2 subunit of the CDC45/MCM2-7/GINS (CMG) DNA helicase cooperates with FACT to evict nucleosomal histones. The evicted histones, containing a panoply of PTMs segregate in nearly equal amounts for deposition onto both new DNA strands. Histone redeposition involves histone chaperone activity of polymerases behind the fork. CAF-1 further associates with PCNA to deposit newly synthesized histones alongside the recycled ones. It receives new histones from ASF1. Circles depict histone pairs, for simplicity. References are provided in the main text.